TMEM41B

Across TCGA patient cohorts, TMEM41B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM41B-associated genes across cancer lineages are FoxM1, PDCD4, and eEF2. Each is linked with TMEM41B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM41B-to-partner and partner-to-TMEM41B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TMEM41B-low versus TMEM41B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM41B→partner) and Y-score (partner→TMEM41B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.347	+3.169	.014	.020	3	1
UCEC	PDCD4 →	-0.537	-3.169	.037	.020	2	2
UCEC	eEF2 →	+0.598	+3.169	.002	.020	2	1
UCEC	eIF4E →	+0.270	+3.000	.019	.036	2	1
UCEC	ERK2 →	+0.258	+3.169	.014	.020	2	1
UCEC	GATA6 →	-0.250	-3.162	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by TMEM41B expression — UCEC

Explore this box plot interactively →