TMEM41B

Across TCGA cell cohorts, TMEM41B mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM41B-associated genes across cancer lineages are SH3GL2, CUEDC2, and C1QBP. Each is linked with TMEM41B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM41B-to-partner and partner-to-TMEM41B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by TMEM41B-low versus TMEM41B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM41B→partner) and Y-score (partner→TMEM41B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.382	+3.474	<.001	.003	3	1
LARGE_INTESTINE	CUEDC2 →	+0.650	+3.212	.001	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.891	+3.301	<.001	.003	3	1
LARGE_INTESTINE	CCNG1 →	+0.771	+3.212	.002	.006	3	1
LARGE_INTESTINE	MRPS15 →	+0.507	+3.299	.002	.004	3	1
LARGE_INTESTINE	RPAP2 →	+0.712	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

SH3GL2 by TMEM41B expression — LARGE_INTESTINE

Explore this box plot interactively →