TMEM41A

Across TCGA pan-cancer cohorts, TMEM41A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMEM41A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM41A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM41A is over-expressed in tumor.

COAD, LSCC, and HNSC are the cancer types where TMEM41A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM41A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.926	<.001	10	view →
LSCC	Male	III,IV	+0.776	<.001	9	view →
HNSC	Male	III,IV	+0.420	<.001	8	view →
LUAD	Female	All	+0.266	<.001	6	view →
CCRCC	All	II,III,IV	+0.245	.002	5	view →
PDAC	All	IV	+1.007	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMEM41A–COAD

Open the COAD breakdown →