TMEM40

Across TCGA patient cohorts, TMEM40 protein abundance is significantly associated with the RNA expression of many other genes, with 10,320 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TMEM40-associated genes across cancer lineages are S100A12, ANXA8, and PERP. Each is linked with TMEM40 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM40-to-partner and partner-to-TMEM40 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM40 versus S100A12 in HNSC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM40→partner) and Y-score (partner→TMEM40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S100A12 →	+2.245	+0.755	<.001	<.001	3	4
LSCC	ANXA8 →	+1.755	+0.610	<.001	<.001	3	4
LSCC	PERP →	+0.749	+0.744	<.001	<.001	3	3
UCEC	RNF180 →	-1.201	-1.393	.005	.001	3	3
HNSC	GDPD2 →	+1.755	+0.705	<.001	<.001	3	3
HNSC	SAMD9 →	+1.190	+0.598	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,320 associations by consensus.

TMEM40 vs S100A12 — HNSC

Explore this scatter interactively →