TMEM40

Across TCGA patient cohorts, TMEM40 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM40-associated genes across cancer lineages are JNK_pT183_Y185, ARID1A, and Di-Ras3. Each is linked with TMEM40 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM40-to-partner and partner-to-TMEM40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TMEM40-low versus TMEM40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM40→partner) and Y-score (partner→TMEM40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.197	-3.156	.033	.020	3	1
UCEC	ARID1A →	-0.290	-2.989	.005	.035	3	1
UCEC	Di-Ras3 →	-0.196	-3.169	.015	.020	2	1
UCEC	MEK1 →	+0.575	+3.169	.004	.020	1	1
UCEC	Paxillin →	+0.406	+3.169	.004	.020	1	1
UCEC	C-Raf →	+0.227	+3.169	.003	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by TMEM40 expression — UCEC

Explore this box plot interactively →