TMEM39B

Across TCGA patient cohorts, TMEM39B protein abundance is significantly associated with the RNA expression of many other genes, with 5,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM39B-associated genes across cancer lineages are HCST, PSTPIP1, and C21orf91. Each is linked with TMEM39B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39B-to-partner and partner-to-TMEM39B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM39B versus HCST in UCEC, with a Pearson correlation of -0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39B→partner) and Y-score (partner→TMEM39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HCST →	-1.916	-0.913	.003	<.001	3	2
UCEC	PSTPIP1 →	-1.203	-0.913	.006	<.001	3	2
UCEC	C21orf91 →	+1.259	+0.991	.007	.001	3	2
UCEC	SYTL3 →	-1.273	-0.679	.006	.004	3	2
UCEC	CXCR2 →	-1.836	-0.943	.001	<.001	3	2
UCEC	NCF1B →	-0.697	-0.678	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,327 associations by consensus.

TMEM39B vs HCST — UCEC

Explore this scatter interactively →