TMEM39B

Across TCGA patient cohorts, TMEM39B mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM39B-associated genes across cancer lineages are HSP70, JNK_pT183_Y185, and Rad50. Each is linked with TMEM39B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39B-to-partner and partner-to-TMEM39B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by TMEM39B-low versus TMEM39B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39B→partner) and Y-score (partner→TMEM39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.375	-2.990	.038	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-1.986	.036	.032	3	1
UCEC	Rad50 →	-0.250	-2.700	.022	.006	3	1
UCEC	VHL →	-0.725	-2.700	.017	.006	3	1
UCEC	Bid →	-0.107	-2.700	.046	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+0.953	+3.479	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

HSP70 by TMEM39B expression — UCEC

Explore this box plot interactively →