TMEM39B

Across TCGA cell cohorts, TMEM39B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,222 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM39B-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Spindle midzone assembly, and RNA export from nucleus. Each is linked with TMEM39B in more than 16 cancer types. Because this analysis shows association rather than direction, both TMEM39B-to-partner and partner-to-TMEM39B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by TMEM39B-low versus TMEM39B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39B→partner) and Y-score (partner→TMEM39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.111	+0.817	.001	<.001	3	17
BREAST	Spindle midzone assembly →	+0.214	+1.060	<.001	<.001	3	15
BREAST	RNA export from nucleus →	+0.112	+1.071	<.001	<.001	3	15
STOMACH	Positive regulation of cell cycle →	+0.068	+1.171	<.001	<.001	3	15
BREAST	Negative regulation of mitotic cell cycle phase transition →	+0.089	+1.322	<.001	<.001	3	14
SOFT_TISSUE	Hair follicle placode formation →	+0.087	+0.504	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,222 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by TMEM39B expression — BONE

Explore this box plot interactively →