TMEM39B

Across TCGA cell cohorts, TMEM39B mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM39B-associated genes across cancer lineages are TACR3, GUCA2A, and KRTAP7-1. Each is linked with TMEM39B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39B-to-partner and partner-to-TMEM39B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACR3 grouped by TMEM39B-low versus TMEM39B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39B→partner) and Y-score (partner→TMEM39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.071	+4.539	<.001	.007	3	1
LARGE_INTESTINE	ASPN →	+0.046	+3.841	<.001	<.001	3	1
LARGE_INTESTINE	OMA1 →	+0.642	+3.064	.008	.009	3	1
LARGE_INTESTINE	PROP1 →	+0.027	+3.054	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TACR3 by TMEM39B expression — BLOOD_Leukemia

Explore this box plot interactively →