TMEM39A

Across TCGA pan-cancer cohorts, TMEM39A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM39A data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM39A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM39A expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where TMEM39A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.177	1.000	.038	8	view →
HNSC	OS	Quartile	IV	0.568	1.000	.044	4	view →
LSCC	DFS	Quartile	All	0.205	0.815	.026	4	view →
LUAD	OS	Median	II,III,IV	0.947	0.570	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM39A–UCEC (DFS)

Open the UCEC breakdown →