TMEM39A

Across TCGA patient cohorts, TMEM39A mutation is significantly associated with the RNA expression of many other genes, with 3,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM39A-associated genes across cancer lineages are MIR4307, EIF3JP1, and FARSBP1. Each is linked with TMEM39A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39A-to-partner and partner-to-TMEM39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4307 grouped by TMEM39A-low versus TMEM39A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39A→partner) and Y-score (partner→TMEM39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4307 →	+0.325	+7.731	<.001	.009	3	2
SKCM	EIF3JP1 →	+0.186	+4.163	<.001	.003	3	2
SKCM	FARSBP1 →	+0.020	+4.163	.003	.003	3	2
LUSC	MTND4LP21 →	+0.151	+4.978	<.001	.005	3	2
UCEC	IGHD2-2 →	+1.333	+1.872	<.001	<.001	3	2
UCEC	DPP4-DT →	+0.318	+2.213	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

MIR4307 by TMEM39A expression — BRCA

Explore this box plot interactively →