TMEM39A

Across TCGA patient cohorts, TMEM39A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM39A-associated genes across cancer lineages are ASNS, EGFR, and eIF4E. Each is linked with TMEM39A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39A-to-partner and partner-to-TMEM39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TMEM39A-low versus TMEM39A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39A→partner) and Y-score (partner→TMEM39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.477	+2.115	<.001	.017	3	2
UCEC	EGFR →	-0.203	-2.115	<.001	.017	3	1
UCEC	eIF4E →	+0.158	+2.247	.041	.001	3	1
UCEC	ERK2 →	+0.230	+3.584	.001	.002	3	1
UCEC	MEK1 →	+0.406	+3.700	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.139	-3.446	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by TMEM39A expression — UCEC

Explore this box plot interactively →