TMEM39A

Across TCGA cell cohorts, TMEM39A mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM39A-associated genes across cancer lineages are C1orf189, F11, and DEFA4. Each is linked with TMEM39A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39A-to-partner and partner-to-TMEM39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by TMEM39A-low versus TMEM39A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39A→partner) and Y-score (partner→TMEM39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1orf189 →	+0.160	+3.736	<.001	.005	3	2
BLOOD_Leukemia	F11 →	+0.103	+4.177	<.001	.001	3	2
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	LMOD2 →	+0.127	+3.643	.003	.005	3	1
LARGE_INTESTINE	BPIFA1 →	+0.117	+3.103	.002	.004	3	1
LARGE_INTESTINE	DAZ4 →	+0.141	+3.562	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C1orf189 by TMEM39A expression — BLOOD_Leukemia

Explore this box plot interactively →