TMEM35A

Across TCGA pan-cancer cohorts, TMEM35A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM35A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM35A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMEM35A is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where TMEM35A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM35A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−2.239	<.001	11	view →
LUAD	Female	II,III,IV	−0.848	<.001	8	view →
LSCC	All	All	−0.731	<.001	6	view →
OV	All	All	−2.063	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM35A–COAD

Open the COAD breakdown →