TMEM33

Across TCGA pan-cancer cohorts, TMEM33 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMEM33’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM33 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM33 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where TMEM33 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM33 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.540	<.001	12	view →
LUAD	Female	All	+0.305	<.001	9	view →
HNSC	Male	III,IV	+0.403	<.001	8	view →
CCRCC	All	All	−0.166	<.001	6	view →
LSCC	Male	All	+0.147	.002	4	view →
OV	All	All	+0.274	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMEM33–COAD

Open the COAD breakdown →