TMEM33

Across TCGA patient cohorts, TMEM33 mutation is significantly associated with the RNA expression of many other genes, with 670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM33-associated genes across cancer lineages are OR51V1, ADM, and CPSF7. Each is linked with TMEM33 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM33-to-partner and partner-to-TMEM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51V1 grouped by TMEM33-low versus TMEM33-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM33→partner) and Y-score (partner→TMEM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR51V1 →	+0.103	+7.741	<.001	.009	3	1
UCEC	ADM →	+1.207	+3.606	<.001	.001	3	1
UCEC	CPSF7 →	+0.408	+3.475	.003	.002	3	1
UCEC	TIRAP →	+0.467	+2.354	.004	.003	3	1
UCEC	DHX37 →	+0.460	+2.386	.001	.003	3	1
UCEC	KCTD14 →	+0.895	+3.032	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 670 associations by consensus.

OR51V1 by TMEM33 expression — COAD

Explore this box plot interactively →