TMEM33

Across TCGA patient cohorts, TMEM33 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM33-associated genes across cancer lineages are PRAS40_pT246, Annexin-1, and TIGAR. Each is linked with TMEM33 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM33-to-partner and partner-to-TMEM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by TMEM33-low versus TMEM33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM33→partner) and Y-score (partner→TMEM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.191	+2.999	.021	.035	3	1
UCEC	Annexin-1 →	+0.660	+3.019	.009	.019	3	1
UCEC	TIGAR →	+0.170	+2.486	.021	.011	3	1
UCEC	ATM →	-0.719	-2.459	<.001	.020	3	1
UCEC	eIF4E →	+0.219	+3.000	.031	.036	2	1
UCEC	MEK1 →	+0.574	+3.169	.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRAS40_pT246 by TMEM33 expression — UCEC

Explore this box plot interactively →