TMEM33

Across TCGA cell cohorts, TMEM33 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,480 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM33-associated GO terms across cancer lineages are Mitochondrial mRNA polyadenylation, CAAX-box protein maturation, and Positive regulation of PERK-mediated unfolded protein response. Each is linked with TMEM33 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM33-to-partner and partner-to-TMEM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial mRNA polyadenylation grouped by TMEM33-low versus TMEM33-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM33→partner) and Y-score (partner→TMEM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Mitochondrial mRNA polyadenylation →	+0.092	+0.619	.007	.003	3	12
LARGE_INTESTINE	CAAX-box protein maturation →	+0.143	+0.806	<.001	<.001	3	11
SKIN	Positive regulation of PERK-mediated unfolded protein response →	+0.189	+0.628	.005	.003	3	11
BLOOD_Lymphoma	Histone mRNA metabolic process →	+0.065	+0.689	<.001	<.001	3	10
PANCREAS	Zinc ion transport →	+0.103	+0.838	.003	.001	3	10
BLOOD_Lymphoma	Transcription by RNA polymerase III →	+0.068	+0.841	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,480 associations by consensus.

Mitochondrial mRNA polyadenylation by TMEM33 expression — PANCREAS

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