TMEM31

Across TCGA patient cohorts, TMEM31 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,019 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TMEM31-associated GO terms across cancer lineages are Protein localization to nucleoplasm, Protein stabilization, and Proton motive force-driven ATP synthesis. Each is linked with TMEM31 in more than 19 cancer types. Because this analysis shows association rather than direction, both TMEM31-to-partner and partner-to-TMEM31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleoplasm grouped by TMEM31-low versus TMEM31-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM31→partner) and Y-score (partner→TMEM31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein localization to nucleoplasm →	+0.050	+0.161	<.001	<.001	3	20
ESCA	Protein stabilization →	+0.058	+0.199	.003	<.001	3	20
ESCA	Proton motive force-driven ATP synthesis →	+0.068	+0.210	.002	<.001	3	20
ESCA	Protein folding →	+0.066	+0.217	.001	<.001	3	19
ESCA	Negative regulation of mRNA processing →	+0.044	+0.166	<.001	<.001	3	19
STAD	Mitochondrial respiratory chain complex assembly →	+0.034	+0.141	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,019 associations by consensus.

Protein localization to nucleoplasm by TMEM31 expression — ESCA

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