TMEM31

Across TCGA patient cohorts, TMEM31 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM31-associated genes across cancer lineages are MEK1, mTOR, and Myosin-IIa_pS1943. Each is linked with TMEM31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM31-to-partner and partner-to-TMEM31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TMEM31-low versus TMEM31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM31→partner) and Y-score (partner→TMEM31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.324	+2.115	.042	.019	3	1
UCEC	mTOR →	-0.158	-2.115	.025	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.256	+2.820	.004	.001	3	1
UCEC	Myosin-IIa →	+0.173	+2.122	.033	.010	3	1
UCEC	Tuberin →	+0.290	+2.331	.013	.019	3	1
UCEC	VEGFR2 →	+0.319	+2.128	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by TMEM31 expression — UCEC

Explore this box plot interactively →