TMEM30B

Across TCGA pan-cancer cohorts, TMEM30B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM30B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM30B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMEM30B is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where TMEM30B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM30B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.570	<.001	11	view →
LSCC	Male	II,III,IV	+0.386	<.001	7	view →
HNSC	All	All	−0.384	.001	6	view →
OV	All	All	−0.980	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM30B–COAD

Open the COAD breakdown →