TMEM30A

Across TCGA pan-cancer cohorts, TMEM30A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMEM30A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TMEM30A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMEM30A is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, HNSC, and CCRCC are the cancer types where TMEM30A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM30A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.599	<.001	9	view →
HNSC	All	All	+0.293	<.001	8	view →
CCRCC	Male	III,IV	+0.472	<.001	7	view →
PDAC	Male	All	−0.481	<.001	4	view →
LUAD	Female	All	+0.245	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMEM30A–LSCC

Open the LSCC breakdown →