Across TCGA pan-cancer cohorts, TMEM273 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM273 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TMEM273 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM273 expression acts as an unfavorable survival marker.

BRCA, STAD, and LUAD are the cancer types where TMEM273 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.198	0.924	<.001	36	view →
STAD	OS	Median	II,III,IV	0.003	0.677	<.001	24	view →
LUAD	OS	Median	All	0.291	0.700	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM273 tumor-vs-normal RNA expression · all TMEM273 data types