Across TCGA patient cohorts, TMEM273 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM273-associated genes across cancer lineages are PCNA, IRS1, and JNK_pT183_Y185. Each is linked with TMEM273 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM273-to-partner and partner-to-TMEM273 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM273→partner) and Y-score (partner→TMEM273) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.265	+2.459	.011	.020	3	2
UCEC	IRS1 →	+0.260	+2.459	.009	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-3.169	.008	.019	3	1
UCEC	JNK2 →	+0.192	+2.817	.046	.036	3	1
UCEC	Ku80 →	+0.334	+2.472	.003	.011	3	1
UCEC	MEK1 →	+0.469	+3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

TMEM273 survival (RNA) · tumor vs normal (RNA) · all TMEM273 data types