TMEM271

Across TCGA pan-cancer cohorts, TMEM271 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMEM271’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM271 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM271 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, LUSC, and HNSC are the cancer types where TMEM271 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM271 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.185	<.001	8	view →
LUSC	All	All	+0.371	<.001	6	view →
HNSC	Female	IV	−0.336	.018	4	view →
READ	All	All	−0.228	.008	4	view →
STAD	Male	All	−0.174	.024	2	view →
BRCA	All	III,IV	−0.023	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMEM271–COAD

Open the COAD breakdown →