TMEM269

Across TCGA cell cohorts, TMEM269 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,702 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM269-associated GO terms across cancer lineages are Spliceosomal complex assembly, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, and Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Each is linked with TMEM269 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM269-to-partner and partner-to-TMEM269 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by TMEM269-low versus TMEM269-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM269→partner) and Y-score (partner→TMEM269) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Spliceosomal complex assembly →	+0.076	+0.398	<.001	.001	3	11
PANCREAS	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.105	+0.144	<.001	.005	3	10
LUNG_SCLC	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.115	+0.424	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.083	+0.248	.002	.004	3	10
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.095	+0.317	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.059	+0.242	.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,702 associations by consensus.

Spliceosomal complex assembly by TMEM269 expression — BLOOD_Leukemia

Explore this box plot interactively →