TMEM268

Across TCGA patient cohorts, TMEM268 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM268-associated genes across cancer lineages are Fibronectin, Ku80, and AMPK_pT172. Each is linked with TMEM268 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM268-to-partner and partner-to-TMEM268 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by TMEM268-low versus TMEM268-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM268→partner) and Y-score (partner→TMEM268) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.378	-3.000	.047	.037	3	1
UCEC	Ku80 →	+0.343	+3.013	.011	.019	3	1
UCEC	AMPK_pT172 →	+0.520	+3.013	.028	.019	3	1
UCEC	Rab11 →	-0.201	-3.000	.016	.037	3	1
UCEC	STAT3_pY705 →	-0.470	-3.000	.001	.037	3	1
UCEC	EGFR_pY1068 →	-0.288	-3.000	.047	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Fibronectin by TMEM268 expression — UCEC

Explore this box plot interactively →