TMEM268

Across TCGA cell cohorts, TMEM268 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,980 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM268-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Viral process, and Glutathione metabolic process. Each is linked with TMEM268 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMEM268-to-partner and partner-to-TMEM268 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by TMEM268-low versus TMEM268-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM268→partner) and Y-score (partner→TMEM268) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of RNA export from nucleus →	+0.163	+0.884	<.001	<.001	2	8
UPPER_AERODIGESTIVE_TRACT	Viral process →	-0.076	-0.748	.001	.005	2	6
KIDNEY	Glutathione metabolic process →	-0.126	-1.175	.009	.008	3	5
PANCREAS	Proteasome core complex assembly →	+0.151	+0.846	<.001	<.001	3	5
BLOOD_Leukemia	Cellular response to peptide →	-0.243	-0.546	<.001	.002	3	5
BLOOD_Leukemia	Membrane protein proteolysis →	-0.083	-0.468	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,980 associations by consensus.

Negative regulation of RNA export from nucleus by TMEM268 expression — STOMACH

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