TMEM267

Across TCGA cell cohorts, TMEM267 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM267-associated genes across cancer lineages are OR13G1, SULT6B1, and BHLHE23. Each is linked with TMEM267 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM267-to-partner and partner-to-TMEM267 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13G1 grouped by TMEM267-low versus TMEM267-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM267→partner) and Y-score (partner→TMEM267) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR13G1 →	+0.018	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	SULT6B1 →	+0.970	+4.078	<.001	.009	3	1
CNS	BHLHE23 →	+0.013	+4.169	<.001	.008	3	1
CNS	CFC1B →	+0.008	+4.772	<.001	.002	3	1
CNS	LELP1 →	+0.066	+4.772	<.001	.002	3	1
CNS	ETDC →	+1.209	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR13G1 by TMEM267 expression — LARGE_INTESTINE

Explore this box plot interactively →