TMEM266

Across TCGA patient cohorts, TMEM266 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,599 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM266-associated proteins across cancer lineages are HDGFL3, NAMPT_S472, and RBSN_S233. Each is linked with TMEM266 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM266-to-partner and partner-to-TMEM266 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM266 versus HDGFL3 in GBM, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM266→partner) and Y-score (partner→TMEM266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HDGFL3 →	+0.411	+0.237	<.001	<.001	3	5
LUAD	NAMPT_S472 →	-1.244	-0.306	<.001	<.001	3	4
PDAC	RBSN_S233 →	+0.648	+0.288	<.001	<.001	3	4
HNSC	MYEF2_S17 →	+1.081	+0.371	<.001	.004	3	4
HNSC	ANK2_S1461 →	+0.634	+0.237	.002	.003	3	4
HNSC	AP3B2_S272 →	+1.065	+0.516	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,599 associations by consensus.

TMEM266 vs HDGFL3 — GBM

Explore this scatter interactively →