TMEM266

Across TCGA patient cohorts, TMEM266 mutation is significantly associated with the RNA expression of many other genes, with 2,168 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM266-associated genes across cancer lineages are DOLPP1, NTMT1, and NELFB. Each is linked with TMEM266 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM266-to-partner and partner-to-TMEM266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOLPP1 grouped by TMEM266-low versus TMEM266-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM266→partner) and Y-score (partner→TMEM266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOLPP1 →	+0.649	+4.332	<.001	<.001	3	3
UCEC	NTMT1 →	+0.661	+2.923	<.001	<.001	3	3
UCEC	NELFB →	+0.504	+3.637	<.001	.001	3	3
UCEC	WDR5 →	+0.524	+3.914	<.001	<.001	3	3
UCEC	RNA5SP35 →	+0.220	+2.567	<.001	.001	3	3
UCEC	CIZ1 →	+0.416	+2.108	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,168 associations by consensus.

DOLPP1 by TMEM266 expression — UCEC

Explore this box plot interactively →