TMEM266

Across TCGA patient cohorts, TMEM266 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM266-associated genes across cancer lineages are ACC1, ACVRL1, and Mre11. Each is linked with TMEM266 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM266-to-partner and partner-to-TMEM266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by TMEM266-low versus TMEM266-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM266→partner) and Y-score (partner→TMEM266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACC1 →	+0.334	+2.182	.020	.033	3	3
UCEC	ACVRL1 →	-0.165	-2.095	.003	.017	3	2
UCEC	Mre11 →	-0.082	-1.807	.021	.027	3	2
UCEC	Annexin-1 →	+0.735	+2.321	<.001	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.516	+2.189	.035	.034	3	2
UCEC	4E-BP1 →	+0.386	+3.614	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC1 by TMEM266 expression — SKCM

Explore this box plot interactively →