TMEM266

Across TCGA cell cohorts, TMEM266 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM266-associated genes across cancer lineages are LYZL2, HMHB1, and CCL13. Each is linked with TMEM266 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM266-to-partner and partner-to-TMEM266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL2 grouped by TMEM266-low versus TMEM266-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM266→partner) and Y-score (partner→TMEM266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LYZL2 →	+0.036	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	HMHB1 →	+0.051	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCL13 →	+0.027	+4.078	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.030	+6.022	<.001	.001	3	1
STOMACH	CT47A6 →	+0.046	+5.285	<.001	.003	3	1
CNS	PRAMEF15 →	+0.352	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LYZL2 by TMEM266 expression — SOFT_TISSUE

Explore this box plot interactively →