TMEM265

Across TCGA cell cohorts, TMEM265 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,288 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TMEM265-associated GO terms across cancer lineages are Regulation of interleukin-2 production, IMP biosynthetic process, and 'de novo' IMP biosynthetic process. Each is linked with TMEM265 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM265-to-partner and partner-to-TMEM265 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of interleukin-2 production grouped by TMEM265-low versus TMEM265-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM265→partner) and Y-score (partner→TMEM265) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of interleukin-2 production →	+0.104	+1.389	<.001	.003	3	11
OVARY	IMP biosynthetic process →	-0.172	-2.337	<.001	<.001	3	11
LARGE_INTESTINE	'de novo' IMP biosynthetic process →	-0.148	-2.243	<.001	<.001	3	11
LARGE_INTESTINE	Cellular response to steroid hormone stimulus →	+0.076	+2.107	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Heme biosynthetic process →	-0.107	-2.462	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	DNA conformation change →	-0.084	-1.485	.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,288 associations by consensus.

Regulation of interleukin-2 production by TMEM265 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →