Across TCGA pan-cancer cohorts, TMEM26 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM26 data layer compared with 16 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TMEM26 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM26 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LSCC, and LUAD are the cancer types where TMEM26 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.655	0.239	.002	8	view →
LSCC	DFS	Tertile	II,III,IV	0.203	0.892	.024	5	view →
LUAD	DFS	Tertile	All	1.000	0.279	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM26 tumor-vs-normal RNA expression · all TMEM26 data types