Across TCGA patient cohorts, TMEM26 mutation is significantly associated with the RNA expression of many other genes, with 978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM26-associated genes across cancer lineages are MFSD12, RNU6-644P, and RNA5SP411. Each is linked with TMEM26 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM26-to-partner and partner-to-TMEM26 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM26→partner) and Y-score (partner→TMEM26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MFSD12 →	+0.936	+3.360	.001	.004	3	3
LIHC	RNU6-644P →	+0.404	+5.355	<.001	.005	3	2
UCEC	RNA5SP411 →	+1.624	+2.171	<.001	.009	3	2
SKCM	HLA-DOB →	-0.900	-3.283	.009	.009	3	2
SKCM	OR2A1-AS1 →	-0.499	-2.611	.005	.006	3	2
UCEC	MON1A →	+0.517	+3.584	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 978 associations by consensus.

Exploration

TMEM26 survival (RNA) · tumor vs normal (RNA) · all TMEM26 data types