Across TCGA patient cohorts, TMEM26 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM26-associated genes across cancer lineages are Caspase-8, A-Raf_pS299, and Paxillin. Each is linked with TMEM26 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM26-to-partner and partner-to-TMEM26 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM26→partner) and Y-score (partner→TMEM26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.370	-2.973	.007	.035	3	2
SKCM	A-Raf_pS299 →	+0.226	+2.820	.002	.035	3	2
UCEC	Paxillin →	+0.333	+3.009	.019	.019	3	1
UCEC	Rab25 →	-0.556	-3.169	.002	.020	3	1
UCEC	STAT3_pY705 →	-0.572	-3.169	<.001	.020	3	1
UCEC	C-Raf →	+0.264	+3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TMEM26 survival (RNA) · tumor vs normal (RNA) · all TMEM26 data types