TMEM258

Across TCGA patient cohorts, TMEM258 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,600 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM258-associated proteins across cancer lineages are ECT2, FEN1, and NASP. Each is linked with TMEM258 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM258-to-partner and partner-to-TMEM258 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM258 versus ECT2 in LSCC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM258→partner) and Y-score (partner→TMEM258) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ECT2 →	+0.576	+0.282	<.001	.002	3	4
LSCC	FEN1 →	+0.471	+0.260	<.001	.001	3	4
BRCA	NASP →	+0.516	+0.361	<.001	<.001	3	4
OV	CCDC86_S18 →	+0.422	+0.620	<.001	<.001	3	3
LSCC	SEPTIN1 →	-0.851	-0.384	<.001	<.001	3	3
LSCC	ADA2 →	-0.622	-0.284	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,600 associations by consensus.

TMEM258 vs ECT2 — LSCC

Explore this scatter interactively →