TMEM258

Across TCGA patient cohorts, TMEM258 protein abundance is significantly associated with the RNA expression of many other genes, with 15,641 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM258-associated genes across cancer lineages are DDX55, NAA25, and UTP25. Each is linked with TMEM258 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM258-to-partner and partner-to-TMEM258 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM258 versus DDX55 in UCEC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM258→partner) and Y-score (partner→TMEM258) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX55 →	-0.848	-0.898	.001	<.001	3	5
CCRCC	NAA25 →	-0.536	-0.693	<.001	<.001	3	4
HNSC	UTP25 →	-0.603	-0.579	.001	<.001	3	4
UCEC	CNOT1 →	-0.661	-0.867	.001	.001	3	4
UCEC	INO80 →	-0.471	-0.951	.001	<.001	3	4
LSCC	IAH1 →	-0.387	-0.429	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,641 associations by consensus.

TMEM258 vs DDX55 — UCEC

Explore this scatter interactively →