TMEM258

Across TCGA patient cohorts, TMEM258 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM258-associated genes across cancer lineages are OR5M9, RPS28P1, and AQP7P4. Each is linked with TMEM258 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM258-to-partner and partner-to-TMEM258 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M9 grouped by TMEM258-low versus TMEM258-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM258→partner) and Y-score (partner→TMEM258) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5M9 →	+0.100	+4.212	<.001	.007	3	2
SKCM	RPS28P1 →	+0.082	+4.039	<.001	.009	3	1
SKCM	AQP7P4 →	+0.064	+3.422	<.001	.006	3	1
SKCM	OR4G2P →	+0.018	+4.408	<.001	.005	3	1
SKCM	RNA5SP71 →	+0.265	+3.180	.003	.004	3	1
SKCM	RNA5S9 →	+0.141	+4.039	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR5M9 by TMEM258 expression — SKCM

Explore this box plot interactively →