TMEM258

Across TCGA cell cohorts, TMEM258 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,003 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM258-associated GO terms across cancer lineages are Mitochondrial electron transport, succinate to ubiquinone, Regulation of protein K48-linked deubiquitination, and Positive regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with TMEM258 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM258-to-partner and partner-to-TMEM258 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial electron transport, succinate to ubiquinone grouped by TMEM258-low versus TMEM258-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM258→partner) and Y-score (partner→TMEM258) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Mitochondrial electron transport, succinate to ubiquinone →	+0.100	+0.959	<.001	<.001	3	13
CNS	Regulation of protein K48-linked deubiquitination →	+0.051	+0.340	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.137	+0.661	.003	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Mitochondrial respiratory chain complex assembly →	+0.063	+0.585	.002	<.001	3	6
BREAST	Chloride transmembrane transport →	-0.065	-0.538	<.001	.002	3	6
BREAST	7-methylguanosine cap hypermethylation →	+0.084	+0.523	.002	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,003 associations by consensus.

Mitochondrial electron transport, succinate to ubiquinone by TMEM258 expression — LIVER

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