TMEM254-AS1

Across TCGA pan-cancer cohorts, TMEM254-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMEM254-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TMEM254-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM254-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and LUAD show a favorable association.

LGG, LUAD, and ACC are the cancer types where TMEM254-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.483	0.318	<.001	51	view →
LUAD	DFS	Tertile	III,IV	0.664	0.287	.001	36	view →
ACC	DFS	Tertile	All	0.240	0.664	.001	26	view →
PAAD	OS	Median	All	0.505	0.264	.004	23	view →
UVM	DFS	Tertile	III,IV	0.230	0.780	.005	21	view →
DLBC	DFS	Tertile	All	0.302	1.000	.003	21	view →
LUSC	OS	Median	II,III,IV	0.492	0.339	.005	19	view →
KIRC	DFS	Quartile	All	0.826	0.548	.004	14	view →
SKCM	OS	Median	II,III,IV	0.366	0.273	.019	9	view →
BLCA	OS	Median	IV	0.180	0.403	.012	9	view →
CHOL	DFS	Quartile	All	0.627	0.163	.029	9	view →
OV	OS	Quartile	All	0.866	0.769	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMEM254-AS1–LGG (DFS)

Open the LGG breakdown →