TMEM253

Across TCGA patient cohorts, TMEM253 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,539 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM253-associated proteins across cancer lineages are SSRP1, HNRNPR, and PLCG2. Each is linked with TMEM253 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM253-to-partner and partner-to-TMEM253 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM253 versus SSRP1 in HNSC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM253→partner) and Y-score (partner→TMEM253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SSRP1 →	+0.340	+0.206	<.001	.004	2	5
GBM	HNRNPR →	+0.317	+0.247	<.001	.001	3	4
LSCC	PLCG2 →	-0.594	-0.301	<.001	<.001	3	4
GBM	ACIN1 →	+0.236	+0.220	.009	.001	2	5
LSCC	ARHGAP15_S43 →	-1.043	-0.288	<.001	<.001	3	4
LSCC	RCSD1 →	-0.610	-0.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,539 associations by consensus.

TMEM253 vs SSRP1 — HNSC

Explore this scatter interactively →