TMEM253

Across TCGA patient cohorts, TMEM253 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM253-associated genes across cancer lineages are RNU6-1082P, LINC01757, and CYCSP43. Each is linked with TMEM253 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM253-to-partner and partner-to-TMEM253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1082P grouped by TMEM253-low versus TMEM253-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM253→partner) and Y-score (partner→TMEM253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1082P →	+0.796	+5.551	<.001	.004	3	1
UCEC	LINC01757 →	+0.246	+5.852	<.001	.003	3	1
UCEC	CYCSP43 →	+0.366	+4.982	<.001	.009	3	1
UCEC	RN7SL83P →	+0.380	+4.982	.001	.009	3	1
UCEC	RN7SKP256 →	+0.676	+5.358	<.001	.006	3	1
UCEC	MIR4774 →	+0.873	+5.852	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RNU6-1082P by TMEM253 expression — UCEC

Explore this box plot interactively →