TMEM253

Across TCGA cell cohorts, TMEM253 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,811 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM253-associated GO terms across cancer lineages are Fatty acid beta-oxidation, Cellular response to nitrosative stress, and GDP-L-fucose biosynthetic process. Each is linked with TMEM253 in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM253-to-partner and partner-to-TMEM253 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid beta-oxidation grouped by TMEM253-low versus TMEM253-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM253→partner) and Y-score (partner→TMEM253) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Fatty acid beta-oxidation →	+0.071	+0.419	.001	.005	3	7
SOFT_TISSUE	Cellular response to nitrosative stress →	-0.115	-0.437	.008	.004	3	7
STOMACH	GDP-L-fucose biosynthetic process →	+0.090	+1.113	.004	.002	3	7
LUNG_NSCLC_LUAD	Sesquiterpenoid metabolic process →	+0.336	+0.423	<.001	<.001	3	7
URINARY_TRACT	Xenobiotic export from cell →	+0.086	+0.615	.009	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Fatty acid oxidation →	+0.052	+0.352	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,811 associations by consensus.

Fatty acid beta-oxidation by TMEM253 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →