TMEM252

Across TCGA patient cohorts, TMEM252 protein abundance is significantly associated with the RNA expression of many other genes, with 171 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TMEM252-associated genes across cancer lineages are PLCB4, ABCD1, and NAGPA. Each is linked with TMEM252 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM252-to-partner and partner-to-TMEM252 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM252 versus PLCB4 in CCRCC, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM252→partner) and Y-score (partner→TMEM252) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PLCB4 →	-1.493	-0.517	.008	.002	3	1
CCRCC	ABCD1 →	-0.474	-0.556	.001	<.001	3	1
CCRCC	NAGPA →	-0.251	-0.509	.001	<.001	3	1
CCRCC	CLCN7 →	-0.367	-0.439	.005	<.001	3	1
CCRCC	ETV2 →	-0.425	-0.718	.002	.001	3	1
CCRCC	GATA3 →	-0.503	-0.668	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

TMEM252 vs PLCB4 — CCRCC

Explore this scatter interactively →