TMEM252

Across TCGA cell cohorts, TMEM252 RNA expression is significantly associated with the go_rna of many other GO terms, with 526 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM252-associated GO terms across cancer lineages are Negative regulation of complement activation, Negative regulation of macrophage colony-stimulating factor signaling pathway, and Negative regulation of cell junction assembly. Each is linked with TMEM252 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM252-to-partner and partner-to-TMEM252 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of complement activation grouped by TMEM252-low versus TMEM252-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM252→partner) and Y-score (partner→TMEM252) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of complement activation →	-0.195	-0.394	<.001	.004	3	4
CNS	Negative regulation of macrophage colony-stimulating factor signaling pathway →	-0.103	-0.105	.001	.001	3	4
LARGE_INTESTINE	Negative regulation of cell junction assembly →	-0.103	-0.231	<.001	.002	3	3
SOFT_TISSUE	Cap-dependent translational initiation →	+0.088	+0.513	<.001	.003	3	3
SOFT_TISSUE	Regulation of complement activation, classical pathway →	-0.220	-0.378	<.001	.006	3	3
SOFT_TISSUE	Telomere maintenance via semi-conservative replication →	+0.098	+0.476	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

Negative regulation of complement activation by TMEM252 expression — SOFT_TISSUE

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