TMEM252

Across TCGA cell cohorts, TMEM252 protein abundance is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM252-associated genes across cancer lineages are MAPK8, MED30, and ARHGAP42. Each is linked with TMEM252 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM252-to-partner and partner-to-TMEM252 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM252 versus MAPK8 in CNS, with a Pearson correlation of -0.93.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM252→partner) and Y-score (partner→TMEM252) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAPK8 →	-0.899	-1.510	.003	<.001	2	2
CNS	MED30 →	-1.320	-1.575	.001	.001	2	2
CNS	ARHGAP42 →	+0.735	+1.470	.003	.005	2	2
CNS	THAP4 →	-0.915	-1.485	.006	.006	2	2
SKIN	QRICH1 →	-0.697	-1.190	<.001	.008	3	1
CNS	SNRPD3 →	-0.815	-1.575	<.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

TMEM252 vs MAPK8 — CNS

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