TMEM251P1

Across TCGA pan-cancer cohorts, TMEM251P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM251P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM251P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM251P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, BRCA, and THCA are the cancer types where TMEM251P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM251P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.122	<.001	8	view →
BRCA	All	II,III,IV	+0.053	.010	6	view →
THCA	All	All	−0.160	.008	3	view →
BLCA	All	All	+0.070	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM251P1–KIRC

Open the KIRC breakdown →