TMEM251

Across TCGA pan-cancer cohorts, TMEM251 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM251 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher TMEM251 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM251 expression acts as an unfavorable survival marker.

PRAD and SKCM are the cancer types where TMEM251 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
SKCM	DFS	Median	II,III,IV	0.291	0.711	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM251–PRAD (DFS)

Open the PRAD breakdown →